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profase

1) The Þrst stage of mitosis during which chromosomes condense, the nuclear envelope disappears, and the centrioles divide and migrate to opposite ends of the cell. 2) The first stage of mitosis and meiosis (although in meiosis this phase is denoted with either a roman numeral I or II) where the chromatin condenses to form chromosomes, nucleolus dissolves, nuclear envelope dissolves, and the spindle begins to form.

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